Hypothalamic and plasma total nitrate/nitrite concentrations in spontaneously hypertensive rats
نویسندگان
چکیده
منابع مشابه
Hypothalamic GABA and sympathetic regulation in spontaneously hypertensive rats.
The posterior hypothalamus contains a sympathoexcitatory system that can be modulated by changes in GABAergic tone. We tested the hypothesis that the GABAergic mechanism in the posterior hypothalamus is altered in spontaneously hypertensive rats (SHR) compared with the Wistar-Kyoto (WKY) control rats. Blood pressure and heart rate were continuously measured in the conscious state; blood samples...
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ESPITE extensive studies on spontaneously hypertensive rats, there have been no studies on the cardiac output except a preliminary work by Albrecht et al,4) which reported a decreasing tendency of cardiac output with age. These authors employed the Stewart-Hamilton principle for the measurement of cardiac output. An attempt was made in this study to measure cardiac output in SHR by applying an ...
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1. Blood pressure was measured and plasma levels of noradrenaline and adrenaline were determined radioenzymatically under basal conditions and after 10% blood volume reduction in blood drawn through catheters previously implanted in young and adult rats of two different genetically hypertensive strains: the Kyoto strain (SHR) and the Milan strain (MHS), and in their respective controls: Wistar-...
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Effects of bunitrolol on mean arterial pressure (MAP) and heart rate (HR) were studied in conscious, unrestrained spontaneously hypertensive (SHR) rats at rest and during handling stress. Propranolol was employed as a reference drug. Plasma drug concentrations were determined to related with the cardiovascular effects of the drugs. Bunitrolol produced a tachycardia for the first 2 hr and a sign...
متن کاملHigher level of plasma nitric oxide in spontaneously hypertensive rats.
We had detected a slightly, but significantly, higher level of plasma nitrite/nitrate in the spontaneously hypertensive rat (SHR) by using the nitric oxide (NO) analyzer (Sievers 280 NOA), which converts nitrate (including nitrate converted from nitrite) to NO. Here, we examined whether the release of NO from protein-bound dinitrosyl nonheme iron complexes (DNIC) contributes to the elevated pla...
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ژورنال
عنوان ژورنال: Experimental Physiology
سال: 1996
ISSN: 0958-0670
DOI: 10.1113/expphysiol.1996.sp003984